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Understanding How Tuberculosis Affects the Body Beyond the Lungs
German researchers studying tuberculosis that spreads beyond the lungs identified unique immune patterns in patients’ blood. These patterns reveal how the body fights the infection and could lead to a simple blood test to replace biopsies.
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Glial Cells in the Retina Are Key for Internal Clock Synchronization
New research has shown that glial cells in the retina are key for neural circuits to adjust to day–night cycles.
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Inner Hair Cells Act as Cellular Architects in the Cochlea
Northwestern Medicine scientists have uncovered how a specific type of cell in the inner ear plays a commanding role in shaping the cellular landscape of the organ responsible for hearing.
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Human Stomach Cells Tweaked To Make Insulin
Researchers genetically engineered stomach organoids to transform them into pancreatic beta cells capable of secreting insulin.
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Metabolism-Powered “Swashing” Lets Bacteria Migrate Without Flagella
Bacteria can spread by sugar-driven “swashing” or by gear-controlled gliding, redefining how microbes colonize surfaces and cause infection.
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Intravenous Immunoglobulin Alternative Therapy Achieves Equal Effect at 1% Dose
Scientists have used their discovery of previously unknown mechanisms in an anti-inflammatory pathway to develop a powerful upgrade: an engineered antibody that delivers the effectiveness of IVIG at fraction of the dose in mice.
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Experimental Cancer Drug SU212 Suppresses Tumor Growth
A new molecule developed by researchers at Oregon Health & Science University offers a promising avenue to treat intractable cases of triple-negative breast cancer — a form of cancer that is notoriously aggressive and lacks effective treatments.
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Liver Organoid Developed To Study How Scarring Starts and Heals
Researchers at Science Tokyo have created a lab-grown liver organoid that mimics regeneration and scarring, offering a new platform to study fibrosis and test therapies that could reverse chronic liver damage.
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Scientists Identify 117 Enzymes That Control Gene Transcription
Researchers uncovered 117 enzymes that modify RNA polymerase II, the key enzyme that transcribes DNA into RNA. The study revealed that even cell-surface kinases like EGFR act within the nucleus to regulate transcription.
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Signaling Pathway Linked to Autoimmune and Inflammatory Damage
According to researchers, IL-15 triggers harmful T-cell activation, but the calcineurin–NFAT pathway acts as a brake, suggesting new therapeutic strategies for autoimmune and viral diseases.
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