News

Discover how PFAS exposure affect the fat metabolism genes of ducklings, which could threaten the birds’ survival and reproduction.

Single-cell RNA sequencing identified distinct immune profiles in extrapulmonary TB, linking interferon–IL-1 signaling to disease progression and paving the way for blood-based diagnostics.

Monash University researchers used CRISPR or a PTPN2 inhibitor to enhance CAR T cell function against solid tumors. Blocking PTPN2 improved T cell persistence and tumor killing in preclinical models, creating long-lived, stem-like CAR T cells.

Scientists at the University of Edinburgh discovered that a Neanderthal DNA region activates a jaw-forming gene, SOX9, more strongly than the human version. The finding helps explain Neanderthals’ larger jaws.

Researchers sequenced the genomes of Northern and Southern Maned Sloths, uncovering distinct conservation challenges. Southern sloths show low genetic diversity, while northern ones face rapid inbreeding due to deforestation.

Researchers discovered that some p53 mutations, particularly R273H, overstimulate DNA replication and trigger immune activation through the cGAS-STING pathway. These tumors responded better to immunotherapy in mouse models.

Discover how a novel acceleration technique allows for the creation of transgenic and gene-edited crops without tissue culture.

A metagenomic study uncovers how gut bacteria influence coronary artery disease, showing a loss of protective species and activation of harmful metabolic pathways.

An international team discovered that ancient viral DNA fragments help regulate genes essential for placental function. The study identified virus-derived enhancers linked to the gene EPS8L1, whose overexpression triggers pre-eclampsia-like changes.

Researchers from Helmholtz Munich found that children of mothers with type 1 diabetes have distinct DNA methylation patterns that may protect against islet autoimmunity. The study identified epigenetic changes in key immune-related genes.